Visual performance with multifocal intraocular lens has been reported in several studies with a multifocal IOL (Acrysof Restor, Tecnis multifocal IOL, and any other diffractive IOL or accommodative IOL) either in photopic or mesopic vision. Cataract surgeons should know which factors can affect the visual outcome, including biometric eye parameters, and the possibilities they have to optimize outcomes based on evidence: using an aspheric IOL to correct spherical aberration, a toric IOL for correcting corneal astigmatism, etc. Exploring how patients can be affected by several factors give the cataract surgeon confidence about when to implant a multifocal intraocular lens or a monofocal IOL in cataract patients.